About Fluocinolone acetonide A synthetic hydrocortisone derivative, Vasoprotective ,reduce skin inflammation. Mechanism of Action of Fluocinolone acetonide Fluocinolone is a topical high potency glucocorticoid. The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.